Elsevier and ExactCure review 20 drugs for Covid-19 therapies

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Elsevier and ExactCure have announced a collaboration aimed at developing personalised model simulations to improve the dosing of Covid-19 related therapies.

ExactCure is a personalised medicine start-up that uses AI technology to reduce medication errors. Combining this platform with data from PharmaPendium, which includes searchable FDA/EMA drug approval documents as well as pharmacokinetic and efficacy data, will help to shed light on potential therapeutic targets.

Fabien Astic, co-founder of ExactCure, said: ‘We have been working with a university hospital in the south of France to provide the clinical pharmacologist and pharmacist the simulation-based suggestions. This allows them to quickly adapt their treatment decisions for a safer and more efficient use of these promising drugs, that while currently still under investigation, could potentially be critical and life-saving for many Covid-19 patients. Through this collaboration with Elsevier to use PharmaPendium’s data we can accelerate this really important work.’

PharmaPendium will provide ExactCure with pharmacokinetic information for approximately 20 approved drugs that have been widely cited in the literature and the news, such as Hydroxychloroquine, Chloroquine, Lopinavir/Ritonavir and Azithromycin, including their regulatory-approval datasets. ExactCure will use this data to build drug-specific exposure models that allow the prediction of pharmacokinetic properties (e.g. Cmax, AUC, Tmax etc).

The first step is to build a simulation based on the patient's age, weight, drug dosage, dosing time and end-time, resulting in a personalised therapeutic window between efficiency and over-exposure. This could potentially reduce the number of adverse drug events. Furthermore, the simulation will be enriched by adding more patient parameters, such as renal status, which is also a critical factor for many severe patients.

'As the pandemic deepens, hundreds of clinical trials have been set up to test existing medications against Covid-19,’ said Olivier Barberan, director of translational medicine solutions at Elsevier. ‘Elsevier has taken its work further by sharing PharmaPendium data to support ExactCure in building the ‘digital twin’ that simulates in-silico the efficacy and interactions of drugs in the body of a patient based on their personal characteristics. This can be extremely helpful for the clinical pharmacologists and frontline doctors in the development of safe and effective treatment. We are looking forward to continuing this work with ExactCure to help reduce the impact of this global pandemic.’